Dr. Borinstein ‘s laboratory investigates epigenetic alterations in Ewing’s Sarcoma (ES) malignant tumor of bone and soft tissue that most often occurs in teenagers and young adults. Although localized ES is often curable, new treatment strategies are desperately needed for patients who present with metastatic disease. Epigenetic alterations are changes that contribute to the regulation of genes within in a cell that does not result in the change in DNA sequence.