Dr. Pauly's research will involve studying the BCL-2 family of proteins with regard to their anti-apoptotic and pro-apoptotic roles in a cell life cycle. My initial project will be working with a druge that inhibits BCL-2 and BCL-XL and studying the impact of this drug on cells that are deficient in the downstream proteins of BCL-2 and BCL-XL in an effort to understand potential side effects of the drug. The long term plan of her research is to then study this drug in childhood lymphoma and/or leukemia.